Akut Radyasyona Bağlı Akciğer Hasarlanmalarında Dimetil Sülfoksitin Radyokoruyucu Etkisinin Tc99m-DTPA Transalveolar Klirens Sintigrafisi ve Histopatolojik Bulgularla Araştırılması

This study aims to investigate the radioprotective effects of dimethyl sulfoxide in acute phase radiation-induced lung injury by technetium-99m-diethylenetriaminepentaacetic acid transalveolar clearance scintigraphy a rabbit model. Twenty white New Zealand rabbits were grouped as (1) control, (2) sham irradiation, (3) irradiation plus sulfoxide, and (4) alone. Right hemithorax regions groups irradiated with single dose 20 Gy Cobalt60 treatment unit. Dimethyl (4.5 gr/kg) was administered intraperitoneally, 30 minutes before irradiation. The performed on 14th day after sacrificed 15th day, both lungs removed for histopathologic evaluation. Administration caused marked prolongation rate diethylenetriaminepentaacetic through alveolocapillary membrane (p=0.028), protected anatomic ultrastructure parenchyma, markedly decreased severity exudate alveoli Our results showed that has safely eliminated inflammatory response induced while not causing any negative alterations structure normal tissue preserving integrity membrane, especially phase. appears be safe well-tolerated protective agent prevention RILI. Technetium-99m-diethylenetriaminepentaacetic is accepted cheap, easily reproducible, sensitive assay monitor radiation toxicity reactions